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Old 07-11-2018, 08:11 PM #1
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Default Surprising new research on schizophrenia meds

I'm not in a situation where I can go find links but I will retell from what I read. For the diagnosis of schizophrenia they started to record how long people lived, on different meds.

People on the newer atypical antipsychotics had the shortest lifespan, and of those, Seroquel/quetiapine was the worst. It is believed that the metabolic changes case premature death.

The med they lived the longest on, was surprisingly the feared Clozaril/clozapine, that needs a lot of followup because some possible serious side effects. It has five black box warnings.

I'm not sure how typical antipsychotics did. They often come with things like akathisia, rigidity and tremor, and the dreaded tardive dyskinesia which can be disabling in itself. Maybe it is worth losing years and not have those side effects but rather metabolic ones?

Anyway, so much for being the safer options because they are newer.

Not meaning to scare anyone, but this really surprised me.
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Old 07-13-2018, 11:20 PM #2
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Default Re: Surprising new research on schizophrenia meds

I'm not surprised. I'm extremely angry at the massive use of the latest "hot" med - Seroquel. Yes, I believe it helps some people. I also believe that it is appallingly overused. It causes massive weight gain and the health problems that go along with that weight gain. It screws with sleep something terrible. AND, for many people, Seroquel doesn't even help much, if at all.
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Old 07-14-2018, 10:20 PM #3
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Default Re: Surprising new research on schizophrenia meds

Not a fan of Seroquel, I find it very tiring but not calming. I get anxiety from it. I got it prescribed for sleeping. I think where I live it will soon be the number one "sleep med" which is a bit bizarre. It wasn't meant as a sleep aid when it was made. Still they say it is safe for daily use as a sleep med. Skeptical...
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Old 07-15-2018, 12:59 AM #4
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Default Re: Surprising new research on schizophrenia meds

Yeah. An anti-psychotic used as a sleep med? Pfffft. Gimme a break.
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Old 07-15-2018, 08:44 AM #5
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Default Re: Surprising new research on schizophrenia meds

Quote:
Originally Posted by *Laurie* View Post
Yeah. An anti-psychotic used as a sleep med? Pfffft. Gimme a break.
I'm with you, Laurie. Using an antipsychotic (first- or second-generation) as a sleep med? Show me the science to back this up. Pfffft...exactly.

I have an "agenda" here, so you can ignore me, but I've never once in my life not been able to discern reality, yet I've been prescribed antipsychotics as sleep meds, "potentiators" of other meds, to "counter" the effects of antidepressants, and in addition to other antipsychotics. Antipsychotic effects are said to be cumulative and irreversible. I really do appreciate that there are people who benefit from them, and I would never presume to argue this point, but...IDK...I'd rather figure out another way. There has to be another way.

Jimi: Of course, you're talking about schizophrenia in your OP, but I think that everyone with an SMI (serious mental illness) should take note.
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Old 07-15-2018, 02:29 PM #6
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Default Re: Surprising new research on schizophrenia meds

I'm on both risperidone and seroquel. The risperidone is an adjunct to my 2 anti-d's and helps with my mood. The serquel helps a lot with my anxiety. But I sometimes feel like a pharmaceutical's guinea pig. I'm worried about long term effects as I'm on relatively high doses of all my meds. But I figure it's a trade off, being able to live relatively well in the short term vs longevity. I come from a notoriously long lived family on my Dad's side (100+'s are normal), so I figure I can afford to lose a few years.
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Old 07-15-2018, 06:13 PM #7
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Default Re: Surprising new research on schizophrenia meds

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Originally Posted by splitimage View Post
I'm on both risperidone and seroquel. The risperidone is an adjunct to my 2 anti-d's and helps with my mood. The serquel helps a lot with my anxiety. But I sometimes feel like a pharmaceutical's guinea pig. I'm worried about long term effects as I'm on relatively high doses of all my meds. But I figure it's a trade off, being able to live relatively well in the short term vs longevity. I come from a notoriously long lived family on my Dad's side (100+'s are normal), so I figure I can afford to lose a few years.

Yeah, but it's not usually a case of someone keeling over dead, or dying peacefully in their sleep. There's usually a long way between sick, dying, and dead. My concern about (specifically) Seroquel is that it can cause major health problems that make life difficult - or even really bad. Intolerable.

Traditionally, I've been extremely in favor of the use of psych meds. Lately, however, I'm feeling like too many meds are way over-prescribed. Using a med like Seroquel as a sleep aid...it seems wrong. Dangerous.
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Old 07-15-2018, 09:31 PM #8
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Default Re: Surprising new research on schizophrenia meds

My question is these drugs are known to kill people and they're still on the market. Drugs for non mental health usage that kill are taken off the market asap. To me this feels like people with mental illness lives are less important to persons with physical illnesses. This is a terrible policy Yeah I know MI concerns the brain so its physical too. I was referring to how the general pubic thinks of MI.
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Old 07-16-2018, 02:52 AM #9
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Default Re: Surprising new research on schizophrenia meds

Is this the study?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471960/

I can't see anything in there that suggests Clozapine is the lowest risk though, it scores as one of the highest for things like weight gain and cardiac disease and high in several other categories.
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Old 07-16-2018, 10:36 AM #10
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Default Re: Surprising new research on schizophrenia meds

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Originally Posted by SparkySmart View Post
Antipsychotic effects are said to be cumulative and irreversible.
I misspoke here. I've personally had antipsychotic effects (EPS/TD) that did, in fact, reverse over time. This is not always the case, though. Second-generation antipsychotics are advertised as being less toxic than first-generation; I'm not qualified to have an opinion about this.
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