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Unread 06-14-2017, 08:20 PM   #1
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Default Did you try an SSNRI? What SSNRI has worked best for you?

Just wanted to get your opinion on which SSNRI has worked best for you and what you were/are taking it for.

https://en.wikipedia.org/wiki/Seroto...take_inhibitor
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Unread 06-14-2017, 08:35 PM   #2
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Default Re: Did you try an SSNRI? What SSNRI has worked best for you?

Cymbalta was halfly decent. When upped from 30 to 60mg. 60mg made me tired and depressed. At 30mg it was OK.
Now NDRI: Bupropion is the best!
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Unread 06-14-2017, 08:36 PM   #3
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Default Re: Did you try an SSNRI? What SSNRI has worked best for you?

Hi, Yes, I'm on duloxitine (Cymbalta). It's an SNRI. I'm taking it for depression, anxiety, and chronic pain (back and general all-over aches). I'm on 90 mg. It is helping my pain and it seems to help my depression quite a bit. Nothing seems to combat anxiety for me.
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Unread 06-14-2017, 08:39 PM   #4
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Default Re: Did you try an SSNRI? What SSNRI has worked best for you?

Quote:
Originally Posted by *Laurie* View Post
Hi, Yes, I'm on duloxitine (Cymbalta). It's an SNRI. I'm taking it for depression, anxiety, and chronic pain (back and general all-over aches). I'm on 90 mg. It is helping my pain and it seems to help my depression quite a bit. Nothing seems to combat anxiety for me.
Awesome, so it's working for you.
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Unread 06-15-2017, 04:53 AM   #5
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Default Re: Did you try an SSNRI? What SSNRI has worked best for you?

Or it's not?
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Unread 06-15-2017, 10:10 AM   #6
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Default Re: Did you try an SSNRI? What SSNRI has worked best for you?

Well, the Cymbalta definitely helps to ease my chronic pain, which helps my depression. It also seems to be a pretty good anti-depressant. But it doesn't help my anxiety much.
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Unread 06-15-2017, 12:06 PM   #7
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Default Re: Did you try an SSNRI? What SSNRI has worked best for you?

Tofranil (and the modified version, Tofranil-PM) is an old school tricylic. In fact, I think Tofranil may be the 1st tca marketed for depression. Elavil seems to be more popular, for some reason.

Anyway...for me, Tofranil (which does SSRNI type stuff, but...different, lol...) helped w/o as much apathy as Cymbalta. This drug is sedating and mine was always prescribed for me to take as a single dose at night, so it doubled as a sleeping pill when I was really "going through it."

Not the best idea if you're on multiple drugs. Also not a good idea if there's a risk of overdose, because it is toxic in overdose. I did find that it works nicely with stimulants, although now I've been told that many doctors these days avoid that combination.

I think it can also help some forms of pain, because tca drugs do something to opiate receptors, I think (?). Not a good idea if one has cardiovascular issues.
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Unread 06-15-2017, 01:33 PM   #8
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Default Re: Did you try an SSNRI? What SSNRI has worked best for you?

You are about right, my friend.
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Unread 06-15-2017, 01:35 PM   #9
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Default Re: Did you try an SSNRI? What SSNRI has worked best for you?

Quote:
Originally Posted by *Laurie* View Post
Well, the Cymbalta definitely helps to ease my chronic pain, which helps my depression. It also seems to be a pretty good anti-depressant. But it doesn't help my anxiety much.
I'm sorry my best advice may sound cliché, please talk with your doctor.
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Unread 06-19-2017, 10:08 PM   #10
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Default Re: Did you try an SSNRI? What SSNRI has worked best for you?

I've taken 3 of them. None of them worked:

Effexor - marginal relief but it pooped out fairly quickly, the withdrawal from this one is horrible

Fetzima - did not respond at all

Cymbalta - nausea, dry heaves, and the most bizarre thing of all - it ironically caused severe muscle stiffness and joint pain which interfered with physical therapy for a chronic back problem, I started pulling muscles all over the place. My pdoc took me off of that one immediately.
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