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Cymbalta (duloxotine hydrochloride)

Overall Rating
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2.84
Rating:

2.84

***
(Out of 5 Stars)
Side Effects
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2.3
Pricing
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2.67
Average Price: $59.70 Thumbs up Recommended By
59% of reviewers (of 68 reviews)
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Cymbaltaź

Generic Name: Duloxetine hydrochloride

Drug Class: Antidepressant, SSNRI

 

Contents

 

Description
This medicine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). This medicine is used to treat depression. This medicine is also used for nerve pain (peripheral neuropathy) in diabetic patients. Your doctor may prescribe this medicine to treat other conditions.
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General Information
This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your healthcare provider. 

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Proper use of this medicine
Follow the directions printed on your prescription label. Ask you doctor or pharmacist if you have any questions about how to take this medicine. This medicine should be taken by mouth. This medicine should be swallowed whole and should not be chewed or crushed, nor should the contents be sprinkled on food or mixed with liquids. All of these might affect the enteric coating. Do not quickly stop this medicine without talking to your doctor.
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Missed Dose
Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses.
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Storage
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture. Throw away any medication that is outdated or no longer needed.
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Possible Side Effects
    • Talk to your doctor if these side effects are bothersome or do not go away:
      • nausea
      • drowsiness
      • dizziness
      • nervousness
      • insomnia
      • headache
      • increased sweating
      • lightheadedness
      • sexual problems
    • A few of the most common side effects with this medicine include:
    • nausea
    • dry mouth
    • constipation
    • fatigue
    • somnolence
    • increased sweating
    • If you experience other bothersome side effects, contact your health care provider.
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Warnings/Precautions
    • Patients and their families should be alert to personality changes such as increased agitation or talk of suicide.
    • Do NOT stop taking this medicine without first talking to your doctor.
    • Alcoholic beverages can increase the effects of this medicine and should be avoided.
    • This medicine may cause drowsiness or dizziness.
    • Before taking this medicine, notify your doctor if you have:
      • history of alcohol abuse
      • narrow-angled glaucoma
      • kidney problems
    • Patient should watch for worsening depression or suicidal tendencies. If you are feeling more agitated, talk to your health care professional.
    • This medicine can cause dizziness or drowsiness.
    • Be cautious when driving or performing other hazardous activities.
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Overdose
Seek medical attention immediately. For non emergencies, contact your local or regional poison control center at 1-800-222-1222.
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Drug Interactions
    • Patients should be advised to inform their physicians if they are taking, or plan to take, any prescription or over-the-counter medications, since there is a potential for interactions.
    • If you are taking a group of medicine called "MAO inhibitors", they cannont be taken with this medicine. Stop the MAO inhibitor 14 days prior to starting this medicine. Your doctor or pharmacist can assist you with this.
    • Before taking any new medications, either prescription or over-the-counter (OTC), talk to your doctor or pharmacist about mixing medicines.
    • Avoid taking St. John's Wort with this medicine.

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Pregnancy/Nursing
Patients should be advised to notify their physician if they become pregnant or intend to become pregnant during therapy. Neonates exposed to SSRIs or SNRIs late in the third trimester have developed complications requiring prolonged hospitalization. (1) Nursing is not recommended while taking this medicine.
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More Information

For more information about this medicine, talk to your healthcare provider.
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Copyright © 2006 PharmClips, Inc. All rights reserved. www.pharmclips.com
This information is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This is general information and should not in any event be construed as specific instructions for individual patients. The publisher does not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein, including any injury and/or damage to any person or property as a matter of product liability, negligence, or otherwise. No warranty, expressed or implied, is made in regard to the contents of this material. The reader is advised to check with their health care provider before making any changes in their drug regimen.
Last reviewed:
  On 8 Aug 2006
  By John M. Grohol, Psy.D.

 

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Reviews
 
adamsmom
Newly Joined

Registered: July 2007
Wed July 11, 2007 Recommended? No | Total Spent: $25.00| Rating: 2 

 
PROS: none
CONS: did not work at all for me

I was more depressed when taking this than I was before I took it.

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jimmyjetta
Newly Joined

Registered: May 2007
Sun May 13, 2007 Recommended? No | Total Spent: None indicated| Rating: 1 

 
PROS: none
CONS: migraines? feeling generally miserable.

Cymbalta is the only antidepressant I've taken to leave me feeling constantly awful. The only way I can describe it is as a coffee-buzz-gone-out-of-control with effects similar to some migraines (BTW, watch the espresso intake while on this drug: I experienced heart palpitations, sweats, and even worse than normal symptoms after coffee one evening).

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MoodyOne
Newly Joined

Registered: April 2007
Wed April 18, 2007 Recommended? Yes | Total Spent: $0.86| Rating: 10 

 
PROS:
CONS: None so far

Cymbalta I LOVE Cymbalta! This has been a miracle drug for me. I was already taking 100mg of Lamictal once per day when I initially started taking Cymbalta. I immediately started having some side effects including dry mouth, nausea, irregular heart beats and decreased appetite. However, my moods were so dramatically improved that I decided to wait it out. After about 10 days the side effects (all but the decreased appetite) went away. When people used to tell me that life wasn't that bad I never believed them. I can breathe now and I feel wonderful in my own skin. I used to break down crying at trivial things. As an added bonus I have lost 14 pounds! Yes, I am a Cymbalta cheerleader, but I do know that this is not for everyone. The docs had me on countless SSRI's before they tried this and none of them ever worked. In fact, they made my condition much, much worse. I hope this helps someone.

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Pomegranate
Grand Poohbah

Registered: February 2007
Location: Florida
Posts: 1611
Mon February 5, 2007 Recommended? Yes | Total Spent: None indicated| Rating: 8 

 
PROS: helped daily pain
CONS: episodes of heavy sweating or hot flashes

I was on Zoloft for major depression and anxiety for several years. But I suffered from joint, muscle and nerve pain daily, most often moderate, sometimes very bad. Switching to Cymbalta helped with the daily moderate pain in legs, upper spine and joints. The very bad lower back and joint pain was not affected but does not occur as often, so it brought me much pain relief along with the same relief from depression as the Zoloft gave me. With the Zoloft I had no side effects after the first two months. With Cymblata the only side effect I have is hot flashes, a couple or so a day. Well worth the pain (and depression) relief to me.

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SecretAngel
Newly Joined

Registered: January 2007
Location: United States
Fri February 2, 2007 Recommended? No | Total Spent: $4.00| Rating: 1 

 
PROS: None
CONS: Horrible side effects when starting

When I started this medication I was so sick for the first week that I could barely get out of bed. I had a horrible headache, and my stomach was so upset that I was not eating or drinking. Eventually it got so bad that I was admitted to the hospital for dehydration.

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ladyprime
New Member

Registered: November 2005
Location: santa maria,ca
Posts: 3
Mon January 29, 2007 Recommended? Yes | Total Spent: None indicated| Rating: 0 

 
PROS: working well for me ..until...
CONS: none, really

until my MH nurse was a jerk and wouldnt give me full dosage to 'punish' me...then i went into a depresion, but out of it now. after reading all these comments, it appears to not work to well for people, but it has been great for me..ive been on wellbutrin 450mg ( this stuff saved my life) ive beenon buspars for about a year, that doing well too, and the cymbalta for about 3-4 months...finally got my little'cocktail'correct

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vanna123
Veteran Member

Registered: July 2005
Location: orange county
Posts: 321
Sat January 27, 2007 Recommended? Yes | Total Spent: None indicated| Rating: 6 

 
PROS: works well on the apin
CONS: weird dreams

had some sucess with the pain -- did not help much with the depression

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Anonymous
Thu December 28, 2006 Recommended? Yes | Total Spent: $30.00| Rating: 9 

 
PROS: helps with nerve pain, self injury urges, and depression
CONS: none

This pill is a wonder drug. My psychiatrist and neurologist both reccomended it. It takes the place of 3 different perscriptions. I would reccomend it to anyone, especially if they have nerve pain!

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sallyoop
Newly Joined

Registered: December 2006
Wed December 20, 2006 Recommended? No | Total Spent: None indicated| Rating: 5 

 
PROS: the world literally seemed brighter
CONS: made me reckless

This medicine made me sleepy and worked wonders for the constant pain I was in due to my depression. I am not sure why I stopped it except that it seemed to worsen my anxiety and did not really help my depression.

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bhill0821
Newly Joined

Registered: December 2006
Sun December 17, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 9 

 
PROS: Great!! Really helps with my feelings
CONS: Side effects, but if you stay on it and take it regular, they subside

Wow, alot of negatives about this medicine. I have been on this medicine for about 2 years. It really works. I stopped taking it for a few weeks and noticed a big difference in my mood and was crying all the time about any little thing. If I have to take this med for the rest of my life, so be it. I am going to get through life on a day by day of dealing with ups and downs by taking the med and enjoying life.

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RollerCoaster
Newly Joined

Registered: December 2006
Wed December 13, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 2 

 
PROS: Calming affect
CONS: Major daytime sleepiness, Sexual problems, Dry mouth

This is the second time I have tried this stuff. It made me so sleepy I thought there was something else wrong with me....constantly yawning and lethargic. It did have a calming effect - like I haven't a care in the world - and would be great if I wanted to lay around the house and sleep all the time, but I am (was/want to be again) a very active person and have work to get done. Although it did not reduce sexual drive, it made climax nearly impossible and even then, not satisfying. Since everyone is affected by these drugs differently, it is hard to make a recommendation....but if you are a physically, sexually active male who relies on being awake and alert for work, don't take this drug!

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superwoman
New Member

Registered: December 2006
Posts: 4
Wed December 6, 2006 Recommended? No | Total Spent: None indicated| Rating: 3 

 
PROS: worked okayish at first
CONS: chronic insomnia, drowsiness,

Been on this med for 4 months. Felt better after about a week of being on it. It gave me some motivation to face my anxiety head on. The side effect of insomnia has not eased in all this time. Takes HOURS to get off to sleep then keep waking during the night. Very lethargic during the day. It seems to have now pooped out and my mood has dropped again. It helped my anxiety to a degree. I wouldn't recommend it because it's effects are not consistent.

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Xilber
Newly Joined

Registered: December 2006
Sat December 2, 2006 Recommended? No | Total Spent: None indicated| Rating: 2 

 
PROS: can't remember any
CONS: sleepiness, constipation

Was on it for a short while for depression. I was extremely tired all the time and constantly constipated.

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dottie
Grand Poohbah

Registered: July 2005
Location: Ohio
Posts: 1526
Fri September 15, 2006 Recommended? No | Total Spent: None indicated| Rating: 9 

 
PROS: elevated my mood
CONS: bizarre dreming, nightmares, insomnia, headache, sinus congestion. Visual problems. Dry mouth,

I can't recommend this. Too many side effects. I have been on it for 2 years and the side effects seem to be worsening. Going to ask my doctor to change to another A-D. Groan.

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Anonymous
Thu September 14, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 6 

 
PROS: elevated my mood
CONS: felt more anxious, lost weight, nausia and supressed apetite and sex drive.

I was on it for one and half months and although I did feel better, I got more panick attacks, and I completely stopped eating and passed out a lot because my blood pressure dropped so low.

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alisandria
Veteran Member

Registered: August 2006
Location: USA
Posts: 303
Fri September 8, 2006 Recommended? No | Total Spent: None indicated| Rating: 6 

 
PROS: N/A
CONS: headache and agitation/anxiety

I tried this on two separate occassions with the hope I could get past the side effects, because I know it's also supposed to be good with neuropathic pain and hopefully would alleviate the pain I suffer. Thing is I could never get past the headaches I got. The second time I tried it I did manage to stay on for a month, but then just had to quit, I had migraines constantly and was experiencing more anxiety than prior to being on it (probably cause of the amount of pain I was in from migraines). Unfortunate because I know that this drug has worked well for many.

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alf0156
Member

Registered: August 2006
Posts: 59
Thu August 31, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 9 

 
PROS: it works
CONS: bad stomic cramps if not taken with a small amount of food

it works

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Anonymous
Sun July 2, 2006 Recommended? Yes | Total Spent: $20.00| Rating: 7 

 
PROS: Adequate anti-depressant
CONS: Sexual side effects. Sleepiness.

It works well with mood stabilizers.

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