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Artane (trihexyphenidyl HCl)

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Generic Name: Trihexyphenidyl HCl Drug Class: Anticholinergics

Description This medicine is classified as an antipsychotic medication and is used to treat all forms of parkinsonism. This medicine may also be prescribed to control extrapyramidal disorders (except tardive dyskinesia) due to central nervous system drugs.

General Information This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your healthcare provider.

Proper use of this medicine Take this medicine exactly as directed by your doctor or pharmacist. This medicine should be taken continually, even if you are feeling better. Follow the directions on your prescription label. Do not take more or less of this medicine that prescribed. Do not share this medicine with other people.

If gastrointestinal upset occurs, take this medication with food.

Missed Dose Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses.

Storage Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture. Throw away any medication that is outdated or no longer needed.

Possible Side Effects This medicine can cause the following potential side effects:

  • blurred vision
  • confusion
  • constipation
  • delusions
  • dizziness
  • drowsiness
  • dry mouth
  • gastrointestinal problems (colon enlargement or paralytic ileus)
  • hallucinations
  • headache
  • increased intraocular pressure
  • memory impairment
  • mild nausea
  • movement disorders
  • nervousness
  • paranoia
  • pupil dilation
  • rapid heartbeat
  • skin rash
  • urinary hesitancy or retention
  • vomiting
  • weakness


  • This medication may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle.
  • Because of increased sedative effects, avoid the use of alcohol or other CNS depressants while taking this medication.
  • This medicine may cause narrow angle glaucoma. Patients should have close monitoring of intraocular pressures. Notify your doctor if you experience blurring of vision while taking this medicine. Blindness has been reported due to aggravation of narrow angle glaucoma.
  • Since this medication may increase the susceptibility to heat stroke, use this medication with caution during hot weather. Promptly report the occurrence of gastrointestinal problems, fever, or heat intolerance since paralytic ileus, hyperthermia, or heat stroke may occur.
  • Abrupt treatment withdrawal may exacerbate parkinsonism or cause neuroleptic malignant syndrome (a potentially fatal symptom complex).
  • Many cough-and-cold products contain ingredients that may add a drowsiness effect. Before you use cough-and-cold medications, ask your doctor or pharmacist about the safe use of those products.

Overdose Seek medical attention immediately. For non emergencies, contact your local or regional poison control center at 1-800-222-1222.

Drug Interactions Let your doctor know if you are taking any of the following types of medications:

  • amantadine (Symmetrel)
  • central nervous system (CNS) depressants (medicines that make you drowsy) such as:
    • sedatives or tranquilizers
    • antidepressants
    • antianxiety medications
    • antipsychotics
    • sleep medications
    • antihistamines (often found in prescription and over-the-counter cold, allergy, and sleep medicines)
    • narcotic pain medications
  • heart medications such as:
    • quinidine
    • digoxin (Lanoxin, Lanoxicaps)
  • monoamine oxidase inhibitors (MAO) inhibitors
  • tricyclic antidepressants

Pregnancy/Nursing Tell your doctor if you are pregnant or planning to become pregnant. It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when this medication is administered to a nursing woman. As with other anticholinergics, trihexyphenidyl may cause suppression of lactation. Therefore, trihexyphenidyl should only be used if the expected benefit to the mother outweighs the potential risk to the infant.

More Information For more information about this medicine, talk to your healthcare provider.

Last reviewed:
On 8 Aug 2006
By John M. Grohol, Psy.D.






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Registered: May 2015
Location: LA
Posts: 79
Wed May 20, 2015 Recommended? Yes | Total Spent: None indicated| Rating: 0 

PROS: it works
CONS: none

I often get approved medicines by using americantrustpills (seriously, this place sucks) free of danger. Unfortunately I use to take plenty of it so low price tag is very important for me.

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Registered: March 2007
Location: wash, u.s.
Tue March 13, 2007 Recommended? Yes | Total Spent: None indicated| Rating: 6 

PROS: helps a little w/ side effects like tremors
CONS: causes enitivity to light(esp. natural)


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Registered: December 2002
Location: DC metro area
Posts: 1366
Thu June 29, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 6 

PROS: helped reduce akathisia & dyskinesias symptoms
CONS: excessive drowsiness

I only recommed this treatment temporarily. I was prescribed this to combat the adverse effects from psychiatric medications (antipsychotics and SSRI's). The psychiatrists had no plan to help me get off any of these meds. Instead, I kept getting more drugs prescribed to treat side effects. Eventually, I was taking 12 different medications a day! I look back to the past and remember hearing the psychiatrists treating me say I'd have to be on these medications for the rest of my life. The drugs didn't take away the PTSD symptoms that I feared. The drugs didn't take away my hopes to die or kill myself. The drugs didn't help me feel healthier. If I was having Extra-Pyramidal Symptoms (including tardive dyskinesia), then why in the hell wasn't there a plan to get me off those drugs that were causing those adverse effects???I've been drug-free for 2 years now. I guess the doctors were wrong in my case.The moral of the story . . . if you have EPS from other psychiatric drugs, then discuss with your doctor his/her plan to help eliminate those symptoms without adding more drugs to the coctail.

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