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Wellbutrin (buproprion HCl)

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Average Price: $14.17 Thumbs up Recommended By
71% of reviewers (of 109 reviews)
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Generic Name: Bupropion HCL byoo-PROP-ee-on

Drug Class: Withdrawal Agents




This medicine is classified as an antidepressant used to treat depression. Your doctor may prescribe this medicine for other conditions such as quitting smoking.

Wellbutrin is used to treat major depressive disorder and seasonal affective disorder. At least one brand of bupropion (Zyban) is used to help people stop smoking by reducing cravings and other withdrawal effects.

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General Information
This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your healthcare provider. 

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Proper use of this medicine
Follow the directions given to you by your doctor. Swallow the tablet whole. Do not crush or chew before swallowing. This medicine is taken orally and may be taken with food if stomach upset occurs. Take this medicine regularly at the same time every day.
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Missed Dose
Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses.
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Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture. Throw away any medication that is outdated or no longer needed.
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Possible Side Effects
    • headache
    • restlessness, agitation
    • dizziness, drowsiness
    • A rare side effect causing a sustained painful erection in males (priaprism) has occurred. If you experience this, talk to your doctor immediately.
    • If you experience other bothersome side effects, contact your health care provider.
    • drowsiness or lightheadedness
    • weight gain
    • dry mouth
    • constipation
    • nervousness
    • trouble sleeping
    • nausea, vomiting, loss of appetite
    • changes in sexual function
    • dry mouth
    • constipation
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    • Do not take bupropion (Zyban) within 14 days of taking an MAO inhibitor.
    • Alcoholic beverages can increase the effects of this medicine and should be avoided.
    • Be cautious when driving or performing other hazardous activities. This medicine can impair judgment.
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Seek medical attention immediately. For non emergencies, contact your local or regional poison control center at 1-800-222-1222.
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Drug Interactions
    • Tell your doctor and pharmacist about all other medicines that you are taking, including non-prescription medicines, nutritional supplements, or herbal products.

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For women: Adequate studies of pregnant women are not available. If you plan on becoming pregnant, talk to your doctor about the benefits versus the risks of using this medicine during pregnancy. For nursing mothers, this medicine is excreted in breast milk in small amounts. Check with your doctor if you plan to nurse your baby.
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More Information

For more information about this medicine, talk to your healthcare provider.
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Tags: depression antidepressant pcdep pcantidep pcsmoke pcsad

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Registered: May 2006
Location: Southern Ontario
Posts: 264
Sat November 25, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 8 

PROS: Increased energy, less depression
CONS: Anxiety, insomnia, restlessness

Found the medication works very well against my depression. I'm at 300mg with the intention of going to 450mg, and I have never had an overly hard time with the side effects. Didn't give me the headaches or stomach aches SSRI's did. Only thing that has been a minor problem was anxiety, but once I got accustomed to the medication it was nonexistent.

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Grand Poohbah

Registered: December 2005
Location: Vermont
Posts: 1529
Sun October 22, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 10 

PROS: did experience relief from depression, anxiety, panic and I lots weight and quit smoking
CONS: none

I would consider taking it again. It worked well while it lasted. I took this medication in comjunction with Lexapro. The combintaion worked well for me for about a year and a half.

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Registered: October 2006
Location: Canada
Posts: 1061
Tue October 10, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 1 

CONS: No response to this med.

This medication had no effect whatsoever on me, even when dosage increased. Had to give up trying this med because depression returning quickly.Didn't do a damn thing for my smoking either!

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Registered: May 2006
Posts: 34
Thu September 28, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 9 

PROS: gives me a bit of an energy boost, have experienced no side effects

has been a great tratment for my depression. no side effects and no wieght gain

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Sun September 24, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 9 

PROS: got rid of my depression a couple winters ago, increased sexual desires

Wellbutrin was added to my mix a couple winters ago when I fell into a depression. It worked very well. I discontinued it when spring came & I would add it again if the depression returned.

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Registered: May 2001
Location: US
Posts: 6683
Fri September 15, 2006 Recommended? No | Total Spent: None indicated| Rating: 3 

PROS: I didn't feel any different with my depression,and it didn't reduce my craving for cigarettes)
CONS: like the other newer AD's (SSRI's) you can have "nerve jerks/jumps",sort of like when the doc checks reflexes.

I have found this med,to be just the same as the others in this category,not effective and over rated. I do stress they may work well for others and I urge those to stick with their treatment plan.

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just me wantng to be free

Registered: October 2004
Location: Kentucky, USA
Posts: 12991
Thu September 14, 2006 Recommended? No | Total Spent: $10.00| Rating: 2 

CONS: anxiety & depression increased, pounding heart, no sleep, lack of appetite & migraine pain

I was perscribed wellbutrin right after prozac. My serious weight loss had already started & this just pushed it into dangerous. On top of that, my heart was pounding hard & I couldn't sleep. My anxiety & depression levels increased. The migraine pain continued to increased which added to the nausea feelings that helped keep me from wanting to eat. This was the weight loss that pushed me into needing medical treatment because my weight wasn't being monitored. I didn't mind the weight loss, so wasn't pushing to stop taking the med except for the migraine pain which I couldn't handle. Once it was determined that it was having such a serious effect on my weight, it was stopped.

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Registered: April 2005
Location: Tornado country
Posts: 2544
Wed September 13, 2006 Recommended? Yes | Total Spent: $8.00| Rating: 10 

PROS: Energy boost, no negative sexual side effects on XL (24 hour) preparation. Much improved mood on SA (12 hour) preparation
CONS: High anxiety, restlessness, irritability, insomnia, constant crying on XL. None on the SA version.

First the XL review: The 150 mg dose seemed to work pretty well, but doctor wanted to eventually get me to 450 mg since that's what "the books" say the dosage should be. At 300 mg I started having vision problems and low blood pressure, had tremors to the point of being a danger behind the wheel, couldn't sleep, constantly cried, snapped at everyone. I also gained 5 pounds within about a week of going to 300 mg. It caused increased sexual desire and response. I'd give this product a rating of 1 overall.Now the SA version: Started at 100 mg once a day for a week and then increased to 200 mg once a day thereafter. This strength and dose delivery seems to be the magic combination. I have all of the benefits with none of the complications. Per my P-doc's orders, I take both pills in the morning instead of splitting the dose so it doesn't cause any sleep disruption. The half life is long enough that it doesn't wear off if you wait 24 hours between doses, even though it's only delivered over 12 hours. I've had little if any weight gain (1-2 pounds at best) even though my appetite has increased. I'm currently 2 pounds below my weight when I started this version. My best guess is that my metabolism increased as well, so my weight has stayed pretty much the same even though my food intake has risen, and I had a healthy appetite to begin with, even with suboptimally treated depression. I'd give this product an overall rating of 10.

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Thu July 13, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 7 

PROS: powerful quickly
CONS: personality change possible

This does what it is says it does, but gave me a totally careful, somewhat reckless attitude about things, caused arrogance and impatience on my part. In addition felt like i was high most of the time and very much in control and great energy boost. (also caused increase in sexual activity)

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