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Anafranil (clomipramine)

Overall Rating
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3.65
Rating:

3.65

*** 1/2
(Out of 5 Stars)
Side Effects
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2.17
Pricing
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4.13
Average Price: None indicated Thumbs down Recommended By
40% of reviewers (of 5 reviews)
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Anafranil®

Generic Name: Clomipramine cloe-MIP-ra-meen

Drug Class: Tricyclic antidepressants, clomipramine

 

Contents

 

Description
Clomipramine is used to relieve symptoms of obsessive-compulsive disorder (OCD) such as recurrent thoughts or feelings and repetitive actions. This medicine may also be used for purposes other than those listed here.
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General Information
This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your healthcare provider. 

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Proper use of this medicine
Take this medicine as directed by your physician. Take each dose with a full glass (8 oz) of water. Clomipramine may be taken several times a day or in one daily dose (usually at bedtime). Follow your doctor's instructions. It may be 4 weeks or more before you start to feel better, but do not stop taking clomipramine without first talking to your doctor.
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Missed Dose
Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses.
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Storage
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture. Throw away any medication that is outdated or no longer needed.
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Possible Side Effects
    • loss of appetite
    • nausea
    • ringing in the ears (less common)
    • weakness
    • agitation
    • tremor or muscle spasms
    • dry mouth
    • headache
    • drowsiness, dizziness, lightheadedness
    • an allergic reaction:
      • difficulty breathing
      • closing the throat
      • swelling of the lips face or tongue
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Warnings/Precautions
    • Use caution when driving, operating machinery, or performing other hazardous activities. Clomipramine may cause drowsiness or dizziness. If you experience drowsiness or dizziness, avoid these activities.
    • Dizziness is likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.
    • Alcoholic beverages can increase the effects of this medicine and should be avoided.
    • Do not stop taking clomipramine suddenly. This could cause symptoms such as nausea, headache, and malaise.
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Overdose
Seek medical attention immediately. U.S. residents can call the national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.
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Drug Interactions
    • Do not take clomipramine if you have taken a monoamine oxidase inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) within the last 14 days.
    • Clomipramine may increase the effects of other drugs that cause drowsiness, including other antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any other prescription or over-the-counter medicines without first talking to your doctor.
    • Drugs other than those listed here may also interact with clomipramine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

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Pregnancy/Nursing
For women, it should be avoided during pregnancy and nursing. As with other medications, if you suspect that you may be pregnant, talk to you physician or pharmacist before using this medication.
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More Information

For more information about this medicine, talk to your healthcare provider.
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Copyright © 2006 PharmClips, Inc. All rights reserved. www.pharmclips.com
This information is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This is general information and should not in any event be construed as specific instructions for individual patients. The publisher does not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein, including any injury and/or damage to any person or property as a matter of product liability, negligence, or otherwise. No warranty, expressed or implied, is made in regard to the contents of this material. The reader is advised to check with their health care provider before making any changes in their drug regimen.
Last reviewed:
  On 8 Aug 2006
  By John M. Grohol, Psy.D.

 

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Reviews
 
crzyflwerchild
New Member

Registered: November 2010
Posts: 1
Sat November 20, 2010 Recommended? No | Total Spent: None indicated| Rating: 1 

 
PROS:
CONS: severe metal and emotional distress

When on this medication for a month, I experienced diziness, fatigue, extreme confusion, depression, suicidal thoughts, irritability, and irrational thoughts/behavior. After I stopped taking the medication, I had worsened depression, confusion, and occasional strange nightmares. Although many of these symptoms could have been unrelated or preexisting, I thought I should inform others of its possible side effects.

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Xava
Newly Joined

Registered: November 2009
Fri November 6, 2009 Recommended? Yes | Total Spent: None indicated| Rating: 10 

 
PROS: no side effects
CONS:

I couldn't see where to edit my first post to add, no one had any weight gain or any other side effects. All have thought it was the best thing to happen to them... and no, I don't work for any pharma company...

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Xava
Newly Joined

Registered: November 2009
Fri November 6, 2009 Recommended? Yes | Total Spent: None indicated| Rating: 10 

 
PROS: only subclinical dosage needed
CONS: none

3 family members have taken clomipramine, it has been a godsend. The youngest only needs a subclinical dosage after other psychotropics did not help her obsessive anxiety/worrying/agitation - it also helped her grandparents with the same problem. Perhaps it is because of genetics that it worked for all 3? But it is worth its weight in gold in our family. It may be an 'old' psychotropic, but it's a 'goodie'.

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joan2
Newly Joined

Registered: January 2007
Fri January 26, 2007 Recommended? No | Total Spent: None indicated| Rating: 5 

 
PROS: helps anxiety and obsessive-compulsive behavior
CONS: somnolence and weight gain

Once again, side effects sabotage the benefits of this medication. I have seen people gain a lot of weight while taking this.

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AlteredState01
Poohbah

Registered: October 2006
Location: Canada
Posts: 1061
Tue October 10, 2006 Recommended? No | Total Spent: None indicated| Rating: 3 

 
PROS: Quick acting - felt medication working within 3 days
CONS: Got really, really fat, fast! (almost 30 lbs in 45 days w/no change in diet. Slowed me down to the point that I felt like a vegetable.

Took this med to help highly aggitated state. Mimimum dosage prescribed to test side effects. (I've experienced alot of side effects with most phych drugs, so am assuming that I am just highly sensitive compared to average).Although calming effects worked very well, the weight gain was just TOO MUCH to handle! It came on so fast and showed no signs of slowing. That really freaked me out - I was afraid the extra lbs would stay forever and would create other difficulties such as high bp and diabetes, which runs in my family. They did not, but it did take almost a year to return to my normal weight range. Other friends I knew that were taking this medication had all ballooned to over 50 lbs (minimum, if they stayed on it)without a change in diet as well (despite the fact label describes it as "increased appetite"). Some that were on higher dosages were like zombies. It slowed them down physically and mentally, and left them unable to show much emotion at all. I would only take it for short periods of time - say, during psychotic-type phases of my illness (BPD). However, I have never stayed in one phase long enough to warrant its re-use.If it didn't have the side effects, I would try using it again, I think.Sorry, can't rate price. Billing of my meds go straight to provincial/federal health plans.

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