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Trazodone (Desyrel)

Overall Rating
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3.38
Rating:

3.38

*** 1/2
(Out of 5 Stars)
Side Effects
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2.65
Pricing
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3.85
Average Price: $13.91 Thumbs up Recommended By
80% of reviewers (of 30 reviews)
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Trazodone

Generic Name: Trazodone TRAZ-oh-done

Drug Class: Antidepressants, miscellaneous

 

Contents

 

Description
This medicine is used for treatment of depression. Your doctor may have prescribed this medicine to help relieve, anxiety, tension or to help you sleep. Your doctor may have prescribed this medicine for other conditions as well.
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General Information
This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your healthcare provider. 

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Proper use of this medicine
Follow the directions given to by your doctor. This medicine should be taken orally on a regular basis. It is best that that you take this medicine at bedtime unless otherwise directed by your doctor. The extended-release tablet and capsule should be swallowed whole. Do not chew, divide, or crush the extended-release tablet or capsule.
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Missed Dose
Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses.
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Storage
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture. Throw away any medication that is outdated or no longer needed.
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Possible Side Effects
    • dizziness, drowsiness
    • agitation, confusion
    • Consult your doctor immediately if you experience prolonged and painful erections.
    • Expected side effects are increased appetite and weight gain.
    • drowsiness, fatigue, dizziness
    • dry mouth
    • Unreported side effects are possible, talk to your healthcare provider if any other symptoms occur.
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Warnings/Precautions
    • Do NOT stop taking this medicine abruptly.
    • This medicine may cause dizziness or drowsiness.
    • Alcoholic beverages can increase the effects of this medicine and should be avoided.
    • Don't drive or perform other tasks that require concentration, until you know how this medicine affects you.
    • This medicine can increase the risk of suicidal thinking and behavior in some children and teens. Parents of children taking antidepressants should watch for signs of worsening depression or unusual changes in behavior.
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Overdose
Seek medical attention immediately. U.S. residents can call the national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.
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Drug Interactions
    • Before taking any new prescription or over-the-counter medication, talk to your doctor or pharmacist. Taking this medicine together with diazepam (Valium) may impair movement ability. Avoid using this medicine with MAO inhibitors. Your doctor or pharmacist can tell you if you are taking an MAO inhibitor.
    • Talk to your doctor if you are taking certain antibiotics such as erythromycin, clarithromycin or azithromycin. This medicine should not be taken with MAO inhibitors.
    • Let your doctor know if you are taking any vitamin supplements or herbal products. St. Johnís Wort should be avoided while taking fluvoxamine due to the increased side effects of too much serotonin.
    • MAO inhibitors should not be taken while taking the following drugs:
      • dexfenfluramine
      • fluoxetine (Prozac)
      • fluvoxamine (Luvox)
      • paroxetine (Paxil)
      • sertraline (Zoloft)
      • venlafaxine (Effexor
      • Effexor XR)
    • Tell your doctor if you are taking other antidepressants, medications for blood pressure, medications for diabetes, sleeping pills, tranquilizers, vitamins or herbs.
    • This medicine may increase the affects antihypertensive drugs, drugs with sedative effects, phenytoin (Dilantin) or fosphenytoin (Celebyx) and tramadol (Ultram).
    • Do not take MAO inhibitors type A with this medicine. If you are not sure if you are taking an MAO inhibitor, talk to your doctor or pharmacist. Certain other antidepressants, clozapine (Clozaril), haloperidol (Haldol), lithium, trazadone, and others may increase the risk of seizures. BEFORE taking any new prescription or over-the-counter medicine, talk to your health care provider.
    • Patients taking MAO inhibitors should not be take this medicine.
    • Nafazodone can decrease the effects of clonidine, methyldopa, diuretics (water pills), warfarin and drugs used to lower blood sugar (hypoglycemics). This medicine can increase the toxic effects of; terfenadine, astemizole, fluoxetine (Prozac), triazolam, alprazolam (Xanax) and phenytoin (Dilantin). Do not take this medicine within 14 days of stopping MAO inhibitors. If you are not sure what an MAO inhibitor is, talk to your doctor or pharmacist. If you are currently taking any of these medicines, talk to your doctor or pharmacist to see if Nefazodone is right for you.
    • Possible drug interactions may occur with phenobarbital causing a decrease in the effect of the medications. Severe blood pressure problems and seizure can occur with taken with MAO inhibitors.
    • Talk with your physician or pharmacist if you are taking other medications.

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Pregnancy/Nursing
If you are pregnant or thinking of becoming pregnant, before taking this medicine talk to your doctor about the benefits versus the risks to your pregnancy. In testing with animals, studies show delayed bone development. Use this medicine only if it clearly necessary. It is advised not to take this medicine while nursing. If you have any concerns, talk to your doctor or pharmacist.
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More Information

Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other benefits. However, studies have shown that a small number of people (especially children/teenages) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with a doctor about the risks and benefits of antidepressant medication, even if the treatment is not for a mental condition. Tell your doctor immediatley if you notice worsening depression, unusual behavior changes, (including possible suicidal thoughts/attempts), or other mental/mood changes. Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.
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Copyright 2006 PharmClips, Inc. All rights reserved. www.pharmclips.com
This information is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This is general information and should not in any event be construed as specific instructions for individual patients. The publisher does not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein, including any injury and/or damage to any person or property as a matter of product liability, negligence, or otherwise. No warranty, expressed or implied, is made in regard to the contents of this material. The reader is advised to check with their health care provider before making any changes in their drug regimen.

Last reviewed:
  On 8 Aug 2006
  By John M. Grohol, Psy.D.


 

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Reviews
 
gubernova
Member

Registered: August 2014
Location: South Texas
Posts: 76
Sun August 17, 2014 Recommended? Yes | Total Spent: $10.00| Rating: 10 

 
PROS: Great sleep aid
CONS: Bad sleep aid if you're not in bed

I've taken this for sleep for the last 18 years. It helps put you to sleep but not very good at sustaining sleep. You must be ready to go to sleep or you can overcome its effect and get pretty excitable. I use in combination with Klonopin and Prazocin to get the sleep I need.

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Baroness4tea
Member

Registered: May 2014
Location: Telford
Posts: 50
Wed May 21, 2014 Recommended? Yes | Total Spent: $16.00| Rating: 8 

 
PROS: Helped with sleep initially
CONS: Sedentary effects wear off after a few hours if you don't fall asleep. Easy to build up a tolerance

Helped me fall asleep for a few days but then found I could fight the sedation and stay awake

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235791113
Junior Member

Registered: March 2014
Location: USA
Posts: 11
Sat March 8, 2014 Recommended? Yes | Total Spent: $15.00| Rating: 8 

 
PROS: Makes you sleepy at night
CONS: Makes you sleepy in the morning (goes away over time)

I was prescribed this for insomnia after melatonin alone did not work and the doctor wanted to use something more long-term than a hypnotic z-drug. At 50 mg, trazodone made me tired at night when combined with 5 mg melatonin. It was not too effective on its own. For the first two weeks, I got REALLY hungry at night after taking this and ate a whole bunch of food in my bed. This went away after a couple weeks. It also was difficult to wake up in the morning for the first few weeks; this became easier over time.

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BPD Ghost
Member

Registered: February 2014
Location: USA
Posts: 33
Sun February 23, 2014 Recommended? No | Total Spent: None indicated| Rating: 2 

 
PROS: Probably adds a little sleepiness
CONS: Not very strong, causes me to fall over randomly.

This is a mass prescribed med that they prescribe to just about everybody in the psyche-wards. I didn't seem to see any benefits in myself or the other patients.

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ginaaa22
Member

Registered: January 2014
Location: Toledo, OH
Posts: 210
Wed January 29, 2014 Recommended? Yes | Total Spent: $5.00| Rating: 10 

 
PROS: good for sleep aid
CONS: makes you too sleepy

good to help sleep and stay asleep

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StormieKnight
Junior Member

Registered: April 2011
Location: Louisiana.
Posts: 15
Sat June 8, 2013 Recommended? Yes | Total Spent: None indicated| Rating: 5 

 
PROS: sleeping like a rock
CONS: sleeping through the entire day, every day

Being a medicated zombie, and sleeping all day long.

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shortandcute
UnWise Elder

Registered: August 2011
Location: Washington State, U.S.A.
Posts: 2436
Thu May 2, 2013 Recommended? Yes | Total Spent: None indicated| Rating: 9 

 
PROS: helps me sleep
CONS: took me a while to get used to it

I love it

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notALICE
Member

Registered: March 2013
Location: Florida (non-native)
Posts: 301
Wed May 1, 2013 Recommended? No | Total Spent: $50.00| Rating: 2 

 
PROS: None I could tell
CONS: Insomnia, agitation, poor concentration, restlessness, short term memory loss.

Not effective, but I was put on this mistakenly under the impression I had Major Depressive Disorder when my diagnosis turned out to be Bipolar I. Without an accompanying mood stabilizer this medication made my symptoms worse.

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DayleJasmine
Junior Member

Registered: June 2012
Location: york
Posts: 9
Fri June 29, 2012 Recommended? Yes | Total Spent: None indicated| Rating: 6 

 
PROS: I can get too sleep 80% of the time
CONS: dizzy next day, feel sick, low appetite, see and hear things

Im currently taking 100mg a night, i sometimes cant feel it sometimes can. i fell horrile the next day. i do reccomend it for sleep but as an anti depressent no.

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+Fight+The+Illness+
Member

Registered: August 2011
Location: Charleston, SC
Posts: 72
Sun January 15, 2012 Recommended? Yes | Total Spent: None indicated| Rating: 6 

 
PROS: Usually helps me sleep for 7-8 hours like it should
CONS: daytime grogginess, slight memory lose

I've recently been put on Trazodone and from what I can tell thus far, it'll be an okay medication for me to be on. I'm taking it for insomnia (along with Ambien) and it seems to also have some kind of effect on my depressive episodes; not much of an effect, but I think I can feel something. The first time I took it, I literally slept for roughly 12 hours; but now I can sleep for about 7 hours, but not always. I've noticed that my memory has gotten a bit worse though. If you wake up before 7 or so hours, you can have some memory lose, which is what's happening with me. So I'm probably going to go back to my pdoc when I can. But overall, it's an okay medication.

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erin654
Junior Member

Registered: May 2011
Location: Orem, UT, USA
Posts: 16
Sat May 21, 2011 Recommended? Yes | Total Spent: $4.00| Rating: 7 

 
PROS: helps me sleep
CONS: sometimes hard to wake up early, tastes awful

I take Trazodone to help me sleep. I have depression-related insomnia. If I can't get the pill to go down just right then it sticks on my tongue or the back of my throat and tastes terrible, making me gag and feel like vomiting. Hard to get the taste out.

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peaceful woman
New Member

Registered: March 2011
Posts: 3
Sat March 19, 2011 Recommended? Yes | Total Spent: $10.00| Rating: 9 

 
PROS: helps with falling asleep and getting back to sleep if you awaken mid-sleep cycle
CONS: none experienced

I have been taking 200 mg of Trazadone at night for over 15 years without any noticeable side effects. I am very please with the fact that it allows me to get at least 7 - 8 hours of sleep per night without any significant morning hangover. I have read the others' posts and am reminded that each of us can have a very unique reaction to the same medication. Some good; some not so good.

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mafub
Member

Registered: February 2010
Location: ROCKY MTN HI
Posts: 85
Fri March 19, 2010 Recommended? Yes | Total Spent: None indicated| Rating: 6 

 
PROS:
CONS:

It helped me sleep, but didn't knock me out or have a drugged feeling such as some people have told me they experienced. I was thankful for it!

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Wiltedpage
Newly Joined

Registered: October 2009
Location: Salisbury, MD
Wed November 4, 2009 Recommended? Yes | Total Spent: $4.00| Rating: 10 

 
PROS: Helping sleep disorders
CONS: gorogy in the morning when first taking it.

I have been taking trazadone for over 4 years and it has been a God send. Before trazadone I can't remember ever getting a good nights sleep, but with it I sleep wonderfully, unless the dog wakes me up,with no side effects.

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thinker22
Magnate

Registered: June 2009
Location: Pac NW
Posts: 2113
Tue July 7, 2009 Recommended? No | Total Spent: $5.00| Rating: 4 

 
PROS: Did help me to sleep
CONS: Had an interaction that caused me to feint

Do not mix Trazodone with even minor amounts of alcohol and other antidepressants. May cause feinting.

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missnsx
Newly Joined

Registered: February 2008
Thu February 28, 2008 Recommended? Yes | Total Spent: None indicated| Rating: 8 

 
PROS: Definately helped me fall asleep
CONS: Crazy dreams!!

I found that it really helped me fall asleep quickly and stay asleep throughout the night. Lunesta and Ambien do not work for me however Trazodone does the trick. The only downside is that it causes me to have very strange and crazy dreams. Some of my friends whom have also taken it have also noted that it caused them to have weird dreams too.

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clskrock
Member

Registered: February 2008
Location: New Mexico
Posts: 98
Fri February 15, 2008 Recommended? Yes | Total Spent: None indicated| Rating: 6 

 
PROS: Makes me drowsy.
CONS: nausea

My dosage was just increased to 150mg. which has upset my stomach.

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Prada
Member

Registered: August 2007
Location: Salt Lake City, Utah, USA
Posts: 26
Fri September 14, 2007 Recommended? Yes | Total Spent: None indicated| Rating: 7 

 
PROS: helped with sleep
CONS: headaches, nausea, dizziness

It worked well, but the side effects were horrible. The 'hangover' feeling was worse than if I were to drink myself to alcohol poisoning.

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cherryblossom
Junior Member

Registered: April 2007
Posts: 15
Sat May 12, 2007 Recommended? Yes | Total Spent: $4.00| Rating: 10 

 
PROS: helps me sleep
CONS: don't know of any

this medicine works good with my other meds.I get so sleepy in about 30 min after I take it.

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mrstumnus
Member

Registered: April 2007
Posts: 20
Thu April 26, 2007 Recommended? Yes | Total Spent: None indicated| Rating: 7 

 
PROS: Great for sleep, good for anxiety and mood.
CONS: Dizziness (short-lived), nasal congestion, water retention.

I found Trazodone helped me sleep tremendously. It did make me feel very dizzy and slightly disorientated but this wears off after about 45 mins. It also causes a rather unpleasant nasal 'blocked' feeling, this is bearable though. It is very good for anxiety, I felt quite 'chilled' and calm, my mood felt considerably better though in a relaxed state, no 'hyper' feeling. Maybe best for short-term sleeping problems or extreme anxiety. No sexual side effects (female), slightly increased appetite and minor weight gain (but this was only due to fluid retention). Some 'hangover' tiredness next day. I assume this would lessen with further use.

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DoubtingThomasina
Junior Member

Registered: April 2007
Location: North Dakota, ASA
Posts: 13
Wed April 11, 2007 Recommended? Yes | Total Spent: None indicated| Rating: 10 

 
PROS: works wonders for insomniacs!
CONS: a little groggy in am

Trazodone is excellent for insomniacs. Knocks you out in 20 minutes or less. Hard to wake in the am but once you do, you feel well rested. It also works will with other antidepressants like Zoloft. Watch out for mild mania. Mood stabilizers necessary for Bipolaroids taking Trazodone.

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Grace03
Member

Registered: March 2007
Location: British Columbia, CANADA
Posts: 45
Thu March 22, 2007 Recommended? Yes | Total Spent: None indicated| Rating: 8 

 
PROS: Seems to control "racing thoughts" associated with Bipolar II. Allows the thoughts to slow down, so I can sleep. Combined with Seroquel=good sleeping meds
CONS: Drowsiness: take at bedtime

;

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Anonymous
Thu December 28, 2006 Recommended? Yes | Total Spent: $30.00| Rating: 7 

 
PROS: works good for sleep...
CONS: ...only if taken with Ambien CR

see my review under Ambien CR.... it worked wonders for helping me sleep as long as I took it with Ambien CR

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bandia
Junior Member

Registered: June 2006
Location: USA
Posts: 9
Sat December 9, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 8 

 
PROS: i fall asleep within minutes and stay asleep
CONS: it lowers my blood pressure

After trying every sleep med known to humankind, Traz hit the spot. It did lower my blood pressure & I briefly went off it & back on Lunesta. Bye-bye sleep! I decided to take the side effect (I sometimes feel "swimmy" & when I do, I just pause and let my heartbeat settle) without hesitation when the docs said it was ok to take Traz if I wanted. I only need to take 12.5 mg a night.

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Amerikasend
Account Suspended

Registered: December 2006
Location: Merryland
Posts: 22
Tue December 5, 2006 Recommended? No | Total Spent: None indicated| Rating: 1 

 
PROS: none
CONS: gave me a stuffy nose and a headache

I was prescribed this for sleep. Didn't help me sleep at all, but it did give me a real bad stuffy nose and a headache. I threw this crap in the garbage.

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Thu September 14, 2006 Recommended? No | Total Spent: None indicated| Rating: 3 

 
PROS: lightened anxiety by a small amount
CONS: did not make me sleepy -at- all.

Was prescribed for both sleep disorder and bipolar. Had a nice lightening of anxiety the next morning, but did not help me to sleep at all even with higher doses.

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eskielover
just me wantng to be free

Registered: October 2004
Location: Kentucky, USA
Posts: 11401
Thu September 14, 2006 Recommended? No | Total Spent: None indicated| Rating: 4 

 
PROS:
CONS: extream sleepiness, dizzyness, along with migraine pain

Trazadone also known as desyrel, had the same effects. The worse part was the dizziness caused by an extreme drop in blood pressure. Along with that came sleepiness & migraine headache pain. The blood pressure drop was the most serious part of taking the med & taking it was immediately stopped.

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DizzyLizzy
Junior Member

Registered: August 2006
Location: New England
Posts: 13
Mon September 11, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 9 

 
PROS: works very well
CONS:

I have been using Trazodone for over 5 years. I take it at bedtime to help me stay asleep, and the doctor prescribed it as a sleep medication... however, it has also helped by keeping my mild depression away. Other anti-depressants were always too strong for my mild depression, but Trazodone has worked great for the mild depression and as an aid to help me sleep.

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MyBestKids2
Elder

Registered: September 2006
Posts: 5677
Mon September 11, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 5 

 
PROS: encourages sleep
CONS: makes me too sleepey

Trazadone should be a last resort for patients who have had an ongong sleep disturbance.

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DaveyJones
Grand Member

Registered: September 2005
Location: Big Orange Country
Posts: 886
Fri September 8, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 8 

 
PROS: Works well for sleep, inexpensive
CONS: Takes a while to get used to

I was prescribed this medicine to help me sleep a number of years ago. It works very well for me used in this way, I sleep 7 - 8 hours a night. When I first started taking it, however, I felt intoxicated when I awoke. This went away after a week or two. I tolerated it because I was finally getting rest again.

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