Forum Reviews Index · Search · Register · Login 

Reviews Index » Medications Previous Product    Next Product

Serzone (nefazodone)

Overall Rating


* 1/2
(Out of 5 Stars)
Side Effects
Average Price: None indicated Thumbs down Recommended By
40% of reviewers (of 5 reviews)
   Post A Reply 


Generic Name: Nefazodone nef-AY-zoe-done

Drug Class: Antidepressants, miscellaneous




This medicine is used for treatment of depression. Your doctor may have prescribed this medicine to help relieve, anxiety, tension or to help you sleep. Your doctor may have prescribed this medicine for other conditions as well.
Top of page 

General Information
This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your healthcare provider. 

Top of page

Proper use of this medicine
Follow the directions given to by your doctor. This medicine should be taken orally on a regular basis. It is best that that you take this medicine at bedtime unless otherwise directed by your doctor. The extended-release tablet and capsule should be swallowed whole. Do not chew, divide, or crush the extended-release tablet or capsule.
Top of page

Missed Dose
Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses.
Top of page

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture. Throw away any medication that is outdated or no longer needed.
Top of page

Possible Side Effects
    • dizziness, drowsiness
    • agitation, confusion
    • Consult your doctor immediately if you experience prolonged and painful erections.
    • Expected side effects are increased appetite and weight gain.
    • drowsiness, fatigue, dizziness
    • dry mouth
    • Unreported side effects are possible, talk to your healthcare provider if any other symptoms occur.
Top of page

    • Do NOT stop taking this medicine abruptly.
    • This medicine may cause dizziness or drowsiness.
    • Alcoholic beverages can increase the effects of this medicine and should be avoided.
    • Don't drive or perform other tasks that require concentration, until you know how this medicine affects you.
    • This medicine can increase the risk of suicidal thinking and behavior in some children and teens. Parents of children taking antidepressants should watch for signs of worsening depression or unusual changes in behavior.
Top of page

Seek medical attention immediately. U.S. residents can call the national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.
Top of page

Drug Interactions
    • Before taking any new prescription or over-the-counter medication, talk to your doctor or pharmacist. Taking this medicine together with diazepam (Valium) may impair movement ability. Avoid using this medicine with MAO inhibitors. Your doctor or pharmacist can tell you if you are taking an MAO inhibitor.
    • Talk to your doctor if you are taking certain antibiotics such as erythromycin, clarithromycin or azithromycin. This medicine should not be taken with MAO inhibitors.
    • Let your doctor know if you are taking any vitamin supplements or herbal products. St. John’s Wort should be avoided while taking fluvoxamine due to the increased side effects of too much serotonin.
    • MAO inhibitors should not be taken while taking the following drugs:
      • dexfenfluramine
      • fluoxetine (Prozac)
      • fluvoxamine (Luvox)
      • paroxetine (Paxil)
      • sertraline (Zoloft)
      • venlafaxine (Effexor
      • Effexor XR)
    • Tell your doctor if you are taking other antidepressants, medications for blood pressure, medications for diabetes, sleeping pills, tranquilizers, vitamins or herbs.
    • This medicine may increase the affects antihypertensive drugs, drugs with sedative effects, phenytoin (Dilantin) or fosphenytoin (Celebyx) and tramadol (Ultram).
    • Do not take MAO inhibitors type A with this medicine. If you are not sure if you are taking an MAO inhibitor, talk to your doctor or pharmacist. Certain other antidepressants, clozapine (Clozaril), haloperidol (Haldol), lithium, trazadone, and others may increase the risk of seizures. BEFORE taking any new prescription or over-the-counter medicine, talk to your health care provider.
    • Patients taking MAO inhibitors should not be take this medicine.
    • Nafazodone can decrease the effects of clonidine, methyldopa, diuretics (water pills), warfarin and drugs used to lower blood sugar (hypoglycemics). This medicine can increase the toxic effects of; terfenadine, astemizole, fluoxetine (Prozac), triazolam, alprazolam (Xanax) and phenytoin (Dilantin). Do not take this medicine within 14 days of stopping MAO inhibitors. If you are not sure what an MAO inhibitor is, talk to your doctor or pharmacist. If you are currently taking any of these medicines, talk to your doctor or pharmacist to see if Nefazodone is right for you.
    • Possible drug interactions may occur with phenobarbital causing a decrease in the effect of the medications. Severe blood pressure problems and seizure can occur with taken with MAO inhibitors.
    • Talk with your physician or pharmacist if you are taking other medications.

Top of page

If you are pregnant or thinking of becoming pregnant, before taking this medicine talk to your doctor about the benefits versus the risks to your pregnancy. In testing with animals, studies show delayed bone development. Use this medicine only if it clearly necessary. It is advised not to take this medicine while nursing. If you have any concerns, talk to your doctor or pharmacist.
Top of page

More Information

Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other benefits. However, studies have shown that a small number of people (especially children/teenages) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with a doctor about the risks and benefits of antidepressant medication, even if the treatment is not for a mental condition. Tell your doctor immediatley if you notice worsening depression, unusual behavior changes, (including possible suicidal thoughts/attempts), or other mental/mood changes. Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.
Top of page

Copyright 2006 PharmClips, Inc. All rights reserved.
This information is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This is general information and should not in any event be construed as specific instructions for individual patients. The publisher does not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein, including any injury and/or damage to any person or property as a matter of product liability, negligence, or otherwise. No warranty, expressed or implied, is made in regard to the contents of this material. The reader is advised to check with their health care provider before making any changes in their drug regimen.

Last reviewed:
  On 8 Aug 2006
  By John M. Grohol, Psy.D.







   Post A Reply 


Registered: May 2015
Location: LA
Posts: 79
Wed May 20, 2015 Recommended? Yes | Total Spent: None indicated| Rating: 0 

PROS: it works
CONS: none

I often order prescribed medications by using americantrustpills (seriously, this place sucks) without danger. The fact is that I use to take tons of it so low price is pretty important for me.

This user is offline
Click here to see this users profile Click here to Send this user a Private Message Find more posts by this user  

Registered: September 2008
Posts: 31
Wed April 22, 2009 Recommended? No | Total Spent: None indicated| Rating: 2 

PROS: No side effects
CONS: No effect period.

It was like taking a sugar pill - it didn't work at all (zero, zip effect), but it didn't have any side effects either.

This user is offline
Click here to see this users profile Click here to Send this user a Private Message Find more posts by this user  
Newly Joined

Registered: May 2007
Sun May 13, 2007 Recommended? Yes | Total Spent: None indicated| Rating: 6 

PROS: it works
CONS: sexual side effects

Antidepressant properties are solid. It works well.I generally only get one side effect from antidepressants: no matter which one it is, if it demonstrates even the smallest possibility of causing sexual side effects then I'm going to be the person who has problems with it.Catch 22.

This user is offline
Click here to see this users profile Click here to Send this user a Private Message Find more posts by this user  
Sun September 24, 2006 Recommended? No | Total Spent: None indicated| Rating: 1 

CONS: didn't seem to help with depression

Didn't work for me. Stayed depressed.

This user is offline
Click here to see this users profile Click here to Send this user a Private Message Find more posts by this user  
just me wantng to be free

Registered: October 2004
Location: Kentucky, USA
Posts: 13133
Thu September 14, 2006 Recommended? No | Total Spent: None indicated| Rating: 4 

CONS: dizziness, migraine pain, lack of appetite

After taking it, the next morning woke up dizzy with a hard time keeping from passing out. It caused nausea & also experienced bad migraine pain. Because the dizziness was an effect from lowered blood pressure that didn't go away after a few days, it was stopped.

This user is offline
Click here to see this users profile Click here to Send this user a Private Message Find more posts by this user  

   Post A Review