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Nortriptyline (Pamelor, Aventyl)

Overall Rating


** 1/2
(Out of 5 Stars)
Side Effects
Average Price: None indicated Thumbs up Recommended By
57% of reviewers (of 7 reviews)
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Generic Name: Nortriptyline nor-TRIP-ti-leen

Drug Class: Antidepressants, tricyclic




This medication is used for short-term treatment of various forms of depression and for chronic neuropathic pain (nerve pain) or to prevent migraine headaches. Your doctor may prescribe this medicine for other conditions as well.
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General Information
This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your healthcare provider. 

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Proper use of this medicine
Take this medicine as directed by your physician. Amitriptyline is taken orally and can be taken with or without food. Dosing varies widely with this medicine depending on the condition that it is being prescribed for. Do not stop taking this medicine abruptly without consulting with your doctor.
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Missed Dose
Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses.
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Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture. Throw away any medication that is outdated or no longer needed.
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Possible Side Effects
    • Unreported side effects are possible, talk to your healthcare provider if any other symptoms occur.
    • An allergic reaction to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, severe dizziness, or trouble breathing.
    • Some common side effects reported with this medicine include:
      • drowsiness or dizziness
      • dry mouth
      • constipation
      • nausea
      • blurred vision
      • headache
      • weight gain
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    • Elderly patients generally should avoid it because this medicine due to an increase in dizziness resulting in falls.
    • This medicine may cause dizziness or drowsiness.
    • Alcoholic beverages can increase the effects of this medicine and should be avoided.
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Seek medical attention immediately. U.S. residents can call the national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.
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Drug Interactions
    • Talk with your physician or pharmacist if you are taking other medications.
    • Possible drug interactions may occur with this medicine and:
      • Phenobarbital
      • MAO inhibitors (severe)

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For women, it should be avoided during pregnancy and nursing. As with other medications, if you suspect that you may be pregnant, talk to you physician or pharmacist before using this medication.
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More Information

Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other benefits. However, studies have shown that a small number of people (especially children/teenages) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with a doctor about the risks and benefits of antidepressant medication, even if the treatment is not for a mental condition. Tell your doctor immediatley if you notice worsening depression, unusual behavior changes, (including possible suicidal thoughts/attempts), or other mental/mood changes. Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.
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Copyright 2006 PharmClips, Inc. All rights reserved.
This information is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This is general information and should not in any event be construed as specific instructions for individual patients. The publisher does not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein, including any injury and/or damage to any person or property as a matter of product liability, negligence, or otherwise. No warranty, expressed or implied, is made in regard to the contents of this material. The reader is advised to check with their health care provider before making any changes in their drug regimen.

Last reviewed:
  On 8 Aug 2006
  By John M. Grohol, Psy.D.







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Registered: May 2015
Location: LA
Posts: 79
Wed May 20, 2015 Recommended? Yes | Total Spent: None indicated| Rating: 0 

PROS: it works
CONS: none

I usually order prescribed drugs via americantrustpills (seriously, this place sucks) free of danger. The fact is that I use to take tons of it so low price is vital for me.

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Junior Member

Registered: May 2014
Location: liverpool
Posts: 6
Fri May 2, 2014 Recommended? Yes | Total Spent: None indicated| Rating: 8 

PROS: cleared my migraines stat
CONS: none

got put on these for mini migraines b ut they r also part of my combination that im on

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Newly Joined

Registered: April 2008
Tue April 22, 2008 Recommended? No | Total Spent: None indicated| Rating: 3 

PROS: helped headaches
CONS: tiredness and twitching

It was hard work being on this med. Even a low dose caused extreme tiredness during the day, yet often caused my mind to race at night. My left eye, left part of my nose, and left side of my mouth also twitch constantly which just feels weird.

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Newly Joined

Registered: March 2006
Location: Southern CA
Thu August 2, 2007 Recommended? No | Total Spent: None indicated| Rating: 1 

PROS: none for me
CONS: Do not drink with this med

Doc put me on this and it made me rage. I told her what it was doing to me and she told me to give it time. I ended up having a few beers with this med and that was a big no no. I freaked out and went crazy on my husband very angry, so bad that I am suprised I didn't get arrested. I told my doc again and she ended up on increasing this med. I did tell her that I have tried imiperime, and desimiperine that made me feel crazy. This med is in the same family as those. My mom and I thought the doctor was the crazy one. My mom said you need to stop taking this med and get a new doctor. Which I did, I quite the med and found a really good doctor!!!

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Newly Joined

Registered: May 2007
Tue May 22, 2007 Recommended? Yes | Total Spent: None indicated| Rating: 10 

PROS: No more Migranes
CONS: Took three days to get out of bed.

I'm on it for migraines and haven't had one since I started taking, I'm on 25 mg. It did knock me out for three days, but once my body adjusted to it I haven't had any side effects, and I'm not overly cheery, I'm still myself. I couldn't give you a price though because my insurance takes care of it.

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Registered: November 2006
Location: Memphis, TN
Posts: 68
Wed November 1, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 8 

PROS: clears brain fog and helps with depression
CONS: dry mouth

Dosing with this med is tricky. You really should have blood tests to see if you are in the therapeutic range.

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just me wantng to be free

Registered: October 2004
Location: Kentucky, USA
Posts: 13336
Thu September 14, 2006 Recommended? No | Total Spent: None indicated| Rating: 3 

CONS: increased anxiety level, migraine pain, dizziness & nausea/lack of appetite

I was prescribed the brand name pamelor of this drug. I ended up not being able to take it for long because it ended up increasing my feelings of anxiety & continuing my feelings of nausea which increased my weight loss. Added to that came the migraine pain & dizziness which was an indication of it effecting my blood pressure level, causing the med to be discontinued soon after starting it.

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