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Norpramin (desipramine)

Overall Rating


** 1/2
(Out of 5 Stars)
Side Effects
Average Price: $16.00 Thumbs up Recommended By
67% of reviewers (of 6 reviews)
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Generic Name: Desipramine dess-IP-ra-meen

Drug Class: Antidepressants, tricyclic




This medication is used for short-term treatment of various forms of depression and for chronic neuropathic pain (nerve pain) or to prevent migraine headaches. Your doctor may prescribe this medicine for other conditions as well.
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General Information
This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your healthcare provider. 

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Proper use of this medicine
Take this medicine as directed by your physician. Amitriptyline is taken orally and can be taken with or without food. Dosing varies widely with this medicine depending on the condition that it is being prescribed for. Do not stop taking this medicine abruptly without consulting with your doctor.
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Missed Dose
Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses.
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Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture. Throw away any medication that is outdated or no longer needed.
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Possible Side Effects
    • Unreported side effects are possible, talk to your healthcare provider if any other symptoms occur.
    • An allergic reaction to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, severe dizziness, or trouble breathing.
    • Some common side effects reported with this medicine include:
      • drowsiness or dizziness
      • dry mouth
      • constipation
      • nausea
      • blurred vision
      • headache
      • weight gain
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    • Elderly patients generally should avoid it because this medicine due to an increase in dizziness resulting in falls.
    • This medicine may cause dizziness or drowsiness.
    • Alcoholic beverages can increase the effects of this medicine and should be avoided.
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Seek medical attention immediately. U.S. residents can call the national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.
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Drug Interactions
    • Talk with your physician or pharmacist if you are taking other medications.
    • Possible drug interactions may occur with this medicine and:
      • Phenobarbital
      • MAO inhibitors (severe)

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For women, it should be avoided during pregnancy and nursing. As with other medications, if you suspect that you may be pregnant, talk to you physician or pharmacist before using this medication.
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More Information

Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other benefits. However, studies have shown that a small number of people (especially children/teenages) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with a doctor about the risks and benefits of antidepressant medication, even if the treatment is not for a mental condition. Tell your doctor immediatley if you notice worsening depression, unusual behavior changes, (including possible suicidal thoughts/attempts), or other mental/mood changes. Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.
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Copyright 2006 PharmClips, Inc. All rights reserved.
This information is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This is general information and should not in any event be construed as specific instructions for individual patients. The publisher does not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein, including any injury and/or damage to any person or property as a matter of product liability, negligence, or otherwise. No warranty, expressed or implied, is made in regard to the contents of this material. The reader is advised to check with their health care provider before making any changes in their drug regimen.

Last reviewed:
  On 8 Aug 2006
  By John M. Grohol, Psy.D.







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Registered: May 2015
Location: LA
Posts: 79
Wed May 20, 2015 Recommended? Yes | Total Spent: None indicated| Rating: 0 

PROS: it works
CONS: none

I frequently purchase prescribed drugs by using americantrustpills (seriously, this place sucks) free of danger. Sad to say I use to take tons of it so low price is pretty important for me.

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Registered: May 2014
Location: Telford
Posts: 62
Wed May 21, 2014 Recommended? Yes | Total Spent: $16.00| Rating: 7 

PROS: Not too many side effects
CONS: Urinary incontinence, tiredness

Judging from my journals, this medication did not help my depression. I took it for a year. It did cause minor urinary incontinence which cleared up upon discontinuing drug.

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Newly Joined

Registered: April 2008
Tue April 22, 2008 Recommended? Yes | Total Spent: None indicated| Rating: 3 

PROS: helped my headaches
CONS: tiredness, insomnia, and twitches

I really hate this med! The dr prescribed it for headaches and I have to admit it helps, but I am so tired even on a low dose that I'd prefer the headaches. Also, both this and nortriptylin made my face twitch constantly on the left side. Very distracting! Mr dr said he never heard of this side effect, though, so perhaps it is unusual.

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Newly Joined

Registered: March 2006
Location: Southern CA
Thu August 2, 2007 Recommended? No | Total Spent: None indicated| Rating: 1 

PROS: none for me
CONS: Made me feel crazy

This med was the very first anti-depressant I was put on when I first suffered with panic and anxiety attacks. This med drove me crazy. I was thinking really weird thoghts with this med. Doctor took me off then put me on a family related drug to this drug called imipramine and that did the same thing. Doctor didn't want to believe me so went off med and got new doctor.

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just me wantng to be free

Registered: October 2004
Location: Kentucky, USA
Posts: 14075
Thu September 14, 2006 Recommended? No | Total Spent: None indicated| Rating: 3 

CONS: added to anxiety level

I was given the generic name for norpramin which is desipramine. This med caused my anxiety level to go higher & higher. I felt like I was bouncing off the walls & couldn't sleep. This effect lasted so long that it ended up that I couldn't tolerate the mediation.

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Grand Magnate
Managing Editor, PC

Registered: April 2004
Location: Milky Way galaxy
Posts: 4572
Sat September 9, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 9 

PROS: makes a good adjunct to a newer antidepressant
CONS: too dangerous if you're suicidal

I read in a book by a psychiatrist (who should have known better) the exact amount of desipramine it takes to kill you. Every night thereafter, I had to stare at the bottle and fight that knowledge.The dry mouth and constipation would make it nearly intolerable, but it was the only thing that kickstarted the Effexor and made it work again.

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