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Fluoxetine (Prozac)

Overall Rating
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2.8
Rating:

2.8

***
(Out of 5 Stars)
Side Effects
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2.26
Pricing
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3.4
Average Price: $5.70 Thumbs up Recommended By
67% of reviewers (of 27 reviews)
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Fluoxetine

Generic Name: Fluoxetine floo-OX-e-teen

Drug Class: Antidepressant, SSRI

 

Contents

 

Description
This medicine is used to treat depression or anxiety. Your doctor may prescribe this medicine for other conditions as well.
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General Information
This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your healthcare provider. 

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Proper use of this medicine
This medicine should be taken about the same time every day, morning or evening and can be taken with or without food. This medicine may take up to 4 weeks to reach full effect, but you may see symptoms of depression improving in as little as 1-2 weeks.
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Missed Dose
Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses.
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Storage
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture. Throw away any medication that is outdated or no longer needed.
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Possible Side Effects
    • dry mouth
    • tremor or muscle spasms
    • nervousness
    • trouble sleeping
    • headache, drowsiness
    • nausea
    • drowsiness
    • insomnia
    • headache
    • increased sweating
    • dizziness, lightheadedness
    • changes in sexual function
    • Unreported side effects are possible, talk to your healthcare provider if any other symptoms occur.
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Warnings/Precautions
    • This medicine may cause drowsiness or dizziness.
    • Alcoholic beverages can increase the effects of this medicine and should be avoided.
    • Smoking cigarettes can decrease the effectiveness of this medicine.
    • If you are planning to have surgery, let your doctor know.
    • Do NOT take this medicine if you have taken an MAO inhibitor [phenelzine (Nardil) or tranylcypromine (Parnate)] in the last two weeks.
    • This medicine can increase the risk of suicidal thinking and behavior in some children and teens. Parents of children taking antidepressants should watch for signs of worsening depression or unusual changes in behavior.
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Overdose
Seek medical attention immediately. U.S. residents can call the national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.
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Drug Interactions
    • If you are taking a tricyclic antidepressant, talk to your doctor before taking this medicine.
    • St. Johnís Wort should be avoided while taking this medicine due to the additive effects of serotonin.
    • Tell your doctor if you are taking any of the following drugs:
      • blood thinners (Coumadin)
      • other antidepressants
      • metoprolol
      • antihistamines
      • carbamazepine (Tegretol)
      • cimetidine (Tagamet)
      • estrogens
      • fluoxetine (Prozac)
      • intraconazole (Sporanox)
      • ketoconazole (Nizoral)
      • levodopa
      • lithium
      • muscle relaxants
      • birth control pills
      • sleeping pills
      • thyroid medications
    • Do not take this medicine with thioridizine, or within 5 weeks of taking this medicine.
    • Caution should be exercised when taking this medicine certain antibiotics, such as erythromycin, clarithromycin, or azithromycin.
    • If you are taking medications for migraines such as Imitrex, talk to your doctor before starting this medicine.
    • This medicine should not be taken with MAO inhibitors. If you think you are taking an MAO inhibitor talk to your doctor or pharmacist.

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Pregnancy/Nursing
If you plan on becoming pregnant, discuss the benefits versus the risks of using this medicine while pregnant. Because this medicine is excreted in the breast milk, nursing mothers should not breastfeed while taking this medicine.
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More Information

Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other benefits. However, studies have shown that a small number of people (especially children/teenages) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with a doctor about the risks and benefits of antidepressant medication, even if the treatment is not for a mental condition. Tell your doctor immediatley if you notice worsening depression, unusual behavior changes, (including possible suicidal thoughts/attempts), or other mental/mood changes. Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.
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Copyright 2006 PharmClips, Inc. All rights reserved. www.pharmclips.com
This information is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This is general information and should not in any event be construed as specific instructions for individual patients. The publisher does not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein, including any injury and/or damage to any person or property as a matter of product liability, negligence, or otherwise. No warranty, expressed or implied, is made in regard to the contents of this material. The reader is advised to check with their health care provider before making any changes in their drug regimen.

Last reviewed:
  On 8 Aug 2006
  By John M. Grohol, Psy.D.


 

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Reviews
 
Sras
New Member

Registered: April 2011
Posts: 1
Thu May 12, 2011 Recommended? Yes | Total Spent: None indicated| Rating: 8 

 
PROS: Stopped suicidal thoughts, some relief from depression
CONS: Sexual dysfunction

For the first 6 weeks I experienced loss of appetite and stomach upsets. This caused some weight loss. My appetite has since returned and the only problems I have is a reduced sex drive and anorgasmia. The good outweighs the bad for me.

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fief1966
Newly Joined

Registered: September 2009
Tue September 29, 2009 Recommended? Yes | Total Spent: None indicated| Rating: 8 

 
PROS: Helped me to enjoy life for the first time, helped with my depression and anxiety
CONS: None, insomnia in the first 3 weeks

I have been taking Fluocitine for about 15 years with a 2 year break about 8 years ago. I started taking it when I was about 28 years old, the best thing I have ever done, I missed so much of my life. I started out with 20 mg, for the last 3-4 years I've been taking 30 mg. I don't think it is working so well anymore though because I have been experiencing more and more anxiety attacks lately. The doctor I went to see convinced me to try it rather taking something to calm me, I was sceptical and scared because of all the negativity around this drug. I am so glad I did it!!

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trixie459
Newly Joined

Registered: August 2008
Tue August 5, 2008 Recommended? Yes | Total Spent: $4.00| Rating: 10 

 
PROS: relieved depression, especially in winter
CONS: stopped working after 18 months

I started taking fluoxetine to help with menopausal symptoms of hot flashes. It never helped with them, but I was amazed at how much calmer and happier I was when taking it. I didn't realize I was depressed--just figured I was a moody person! My life improved dramatically thanks to fluoxetine. Unfortunately, it lost its effectiveness, even at different doses. I've been trying for a year to find a med that works as well. Therapy certainly helps, but it's not enough.

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SeraphNeophyte
Junior Member

Registered: June 2008
Location: South Africa
Posts: 7
Tue July 1, 2008 Recommended? Yes | Total Spent: None indicated| Rating: 2 

 
PROS: Some depressive relief
CONS: Sleep difficulty, Increased suicidality, Zombified during initial treatment

Depression is only about 20% of my problem...the rest wasn't even touched

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Hermetic
Newly Joined

Registered: June 2008
Sun June 22, 2008 Recommended? Yes | Total Spent: None indicated| Rating: 6 

 
PROS: Uplifted depression, reduced anxiety, improved concentration and stabilized my mood.
CONS: Numbness, decreased creativity, descreased sex drive

This was the only medication that was able to stabilize my mood over a long period of time. It unfortunately supressed a lot of my emotions and reduced my creativity. It also made me somewhat apathetic.

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sarahmp
Newly Joined

Registered: September 2007
Location: honolulu, hawaii
Fri January 25, 2008 Recommended? Yes | Total Spent: $10.00| Rating: 6 

 
PROS: makes me feel somewhat happier
CONS: side effects

Although prozac made me feel better, it also gave me extremely severe migranes. There were times when I would still consider suicide, even on the drug.

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haleyshea
Newly Joined

Registered: December 2007
Wed December 5, 2007 Recommended? No | Total Spent: None indicated| Rating: 1 

 
PROS: slight relief of depression
CONS: nausea, constipation, headaches

Half the time I took it I ended up throwing up. In combination with the headaches I was pretty much in constant pain. It helped my depression a little, but the side effects were too bad and negated any help Prozac gave me. Yeah, I felt a little better, but I wanted to die everything hurt so bad.

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Gianna
New Member

Registered: October 2007
Location: NC
Posts: 1
Thu October 25, 2007 Recommended? No | Total Spent: None indicated| Rating: 1 

 
PROS: none
CONS: gave me the worst anxiety attacks I've ever had in my life

all SSRI's are dangerous and ineffective for me

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buzzie
Newly Joined

Registered: March 2006
Location: Southern CA
Thu August 2, 2007 Recommended? Yes | Total Spent: $5.00| Rating: 10 

 
PROS: Depression
CONS: none that I know of

It has helped me big time. Helped with my depression. On 20 mg. for now. Was on clexa which was also good except for the weight gain. The weight gain made me more insecure so Prozac has helped with not gaining weight.

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sweetleaf
Junior Member

Registered: July 2007
Location: south florida
Posts: 15
Sun July 29, 2007 Recommended? Yes | Total Spent: None indicated| Rating: 9 

 
PROS: excellent 4 depression, almost no side effects
CONS: makes hypomania worse

If not for Prozac, I'd have checked myself outta here years ago. On it, my depression fades away and I live a productive life. It lowered my sex drive to a normal human level. I was misdiagnosed unipolar and now know I'm bipolar. Haven't successfully found a mood stabilizer yet to go along with the Prozac, so I'm dealing with the hypomania. My family's happier when I'm on the Prozac--I clean the house more!

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EnigmaCat
Newly Joined

Registered: March 2007
Wed June 6, 2007 Recommended? Yes | Total Spent: $0.13| Rating: 10 

 
PROS: helped fight depression. reduced OCD symptoms. got rid of mental fog and daily stress headaches.
CONS: metalic taste for the first month.

fluoxetine is a miracle drug as far as I'm concerned. at 40 mgs a day, my depression has largely lifted. my anxiety has decreased some. my OCD is less obsessive and compulsive. my chronic headaches are gone, as is the brain fog. thinking doesn't physically hurt any longer. my creative drive and my interest in life have returned.

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nibbanalice
Newly Joined

Registered: May 2007
Thu May 24, 2007 Recommended? No | Total Spent: None indicated| Rating: 1 

 
PROS: nothing positive
CONS: very bad

Did not help me at all. I got sick. kept me in bed. Brain stopped functioning. I hated it.

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jimmyjetta
Newly Joined

Registered: May 2007
Sun May 13, 2007 Recommended? Yes | Total Spent: None indicated| Rating: 6 

 
PROS: it works
CONS: sexual side effects

Antidepressant properties are solid. It works well.I generally only get one side effect from antidepressants: no matter which one it is, if it demonstrates even the smallest possibility of causing sexual side effects then I'm going to be the person who has problems with it.Catch 22.

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DePressMe
Grand Magnate

Registered: March 2007
Location: Indiana
Posts: 3920
Fri April 27, 2007 Recommended? No | Total Spent: $0.75| Rating: 2 

 
PROS: None
CONS: Did not help my depression and it caused some sexual dysfunction.

This medication did not help my depression. It did cause sexualy dysfunction, so I stopped taking it.

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loupopeye22
New Member

Registered: March 2007
Posts: 1
Fri March 23, 2007 Recommended? No | Total Spent: None indicated| Rating: 1 

 
PROS: can't think of any
CONS: lots

Prozac was the first medication given when I was severe depressive illness, off work for more than 7 months. During that time, I was from the lowest ebb to the highest energy which had causing havoc in my family. I threw all the stuff and cleaned in the kitchen vigorously until I calmed down as if nothing had happened in the house. My sisters and my grandmother had kept asking where their stuff were. I vaguely remembered and felt remorsely guilty about it. Went back to my doctor and had decided to stop the meds and changed to doxepin.

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Anonymous
Sun March 4, 2007 Recommended? Yes | Total Spent: None indicated| Rating: 4 

 
PROS: it helped to clear my thoughts
CONS: nausea, no sleep

it did what it was prescribed to do which was to clear my head a little to enable me to think clearer

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boomslang
Junior Member

Registered: February 2007
Posts: 16
Wed February 28, 2007 Recommended? No | Total Spent: None indicated| Rating: 4 

 
PROS: none
CONS: sent me into a wild manic episode that almost got me killed and threw me out of college, though I was misdiagnosed as Unipolar when I am actually Bipolar

I was diagnosed with Unipolar Depression, Tourette's syndrome, ADHD, OCD. I was put on this and Strattera. I collapsed from a horrible manic episode as a Junior in college and was afterwards diagnosed with Bipolar I, along with the other diagnoses.DO NOT TAKE IF YOU ARE BIPOLARIF YOU HAVE BEEN DIAGNOSED UNIPOLAR AND ARE HAVING MANIC SYMPTOMS TELL YOUR DOCTOR ASAP

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pinacolada
Newly Joined

Registered: February 2007
Sun February 25, 2007 Recommended? Yes | Total Spent: None indicated| Rating: 6 

 
PROS: less frustrated, depression not prevalent constantly, confidence boost, creative imagination inspired
CONS: somewhat more suicidal during difficulties, do not recall much while on medication, impulsiveness

The first year of taking it really improved my self esttem and sparked my creative outlet intrest, however out of nowhere I would either feel compelled to give into impulse without hessitation. This can be dangerous. and crying jags would come on out of nowhere. Then it was if after a period of time i felt as though Life was some dream state and felt apathetic. however i do rember if only used for a short period it was signigant in helping me cope with the most unstable part of my life.

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mama2ak
New Member

Registered: December 2006
Location: Minnesota
Posts: 4
Sun December 31, 2006 Recommended? Yes | Total Spent: $10.00| Rating: 8 

 
PROS: Price, low side effects
CONS: Build up a tolerance

The price is right, the side effects are low, but I didn't feel like it worked as effectively as Paxil or Celexa.

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URIIADDIVME
Member

Registered: September 2006
Posts: 38
Mon December 18, 2006 Recommended? No | Total Spent: None indicated| Rating: 1 

 
PROS:
CONS: tremor, nausea, constant vomiting, extremely painful hemorroids, dizzyness sleep disturbance

I spent three months in severe discomfort. Discontinuing treatment returned me to a tolerable experience.

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AlteredState01
Poohbah

Registered: October 2006
Location: Canada
Posts: 1061
Tue October 10, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 5 

 
PROS: Keeps me from spiralling into deep depressive states.
CONS: Not so easy to take oneself off this medication if used for long periods.

Only medication that hasn't created problems with side effects, other than, well, killing what's left of my sexual desires. Didn't gain weight, though!!Have been taking this med for over 15 years and at various dosages. Now taking minimum dosage (10 mgs)daily.Side effects are difficult to deal with when trying to ween off this medication (with proper supervision, of course). I experienced weird head rushes, dizziness, moodiness. Felt myself destablizing very quickly (even before weening process completed) and began treatment again at my regular dosage. Have not tried again since (5 years). Too scared to, really.

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endless_hysteria
New Member

Registered: October 2006
Location: Worcester, UK
Posts: 2
Fri October 6, 2006 Recommended? No | Total Spent: None indicated| Rating: 2 

 
PROS: none
CONS: gave me acid reflux

It not only didn't work on me, but it gave me acid reflux and made me very ill for 6 months

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Sun September 24, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 5 

 
PROS: took care of depression
CONS: pushed me into a hypo manic state, stopped working after about 6 weeks& had to keep increasing dosage

Since I wasn't diagnosed with bipolar at the time I was on this, it was used alone with no mood stabilizer & it pushed me into a hypo manic state which I really enjoyed after being so depressed for so long.

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darkeyes
Elder

Registered: May 2001
Location: US
Posts: 6683
Fri September 15, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 6 

 
PROS: helped reduce some depression and the fatigue from depression
CONS: started to poop out,losing emotion,and started with "brain zaps"

Because of being wrongly DXed,I cannot say the antidepressants used today (SSRI's) do not work well,but I did get some reduction in my depression.

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eskielover
just me wantng to be free

Registered: October 2004
Location: Kentucky, USA
Posts: 11774
Thu September 14, 2006 Recommended? No | Total Spent: $10.00| Rating: 2 

 
PROS:
CONS: anxiety attacks worse, increased depression, loss of appetite, suicidal

fluoxetine goes also under brand name of prozac. The use of this as prozac pushed my weight loss to a dangerously low level which required medical treatment. It also caused my anxiety & depression levels to increase & even ended I reaulted in having several suicidal attempts during its use.

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jennie
Poohbah

Registered: December 2002
Location: DC metro area
Posts: 1366
Wed September 13, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 4 

 
PROS:
CONS: migraines

After having difficulties with another SSRI, my psychiatrist switched me to this medication. I had to stop this med because it caused debiliating migraines which prevented me from working my job for a week.

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Tue September 12, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 1 

 
PROS: none that I experienced
CONS: too many for me

this drug is otherwise known as prozac. I recieved this drug back when it was first coming on the market and not much was known about it. I became even more unstable on it to the point where even now I have no memory of what I did while on it. All I do know is that I remember seeing colored blips in front of my eyes which turned out to be that all I did at work while on this medication was play donkey kong on the office computer. When I answered the phone during my time on duty at this college where I worked I basically in not so clean language told the caller I didn't work there and to leave me alone and never call again. I have also been told I was constantly experiencing hot flashes and cold flashes for I was either stripping my clothes in the college lounge or was taking everyone elses spare clothing because I was freezing. I had a roommate at one point after I had been off it for a year and she experienced an increase in the need to burn herself with a glue gun and one night told me she was gonig to kill herself and was extremely serious and activated about it so I had to go to a neighbors house and call the police while another friend kept her on the phone.I now know I have DID so looking at all this it tells me that if a person has DID and are put on this medication I highly recommend VERY close monitoring by the prescribing physician and the client being prescribed this medication should attend many med checks while starting on the medication so that if it cases more dissociative problems the medication can be adjusted or discontinued.I am leaving the yes on for recommendation because one persons flop medication can be another persons miracle drug. So I don't feel its up to me to recommed or not a drug. for me this drug was a disaster but I do have some friends that have had good luck with it.

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