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Doxepin (Adapin)

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Generic Name: Doxepin DOX-e-pin

Drug Class: Antidepressants, tricyclic




This medication is used for short-term treatment of various forms of depression and for chronic neuropathic pain (nerve pain) or to prevent migraine headaches. Your doctor may prescribe this medicine for other conditions as well.
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General Information
This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your healthcare provider. 

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Proper use of this medicine
Take this medicine as directed by your physician. Amitriptyline is taken orally and can be taken with or without food. Dosing varies widely with this medicine depending on the condition that it is being prescribed for. Do not stop taking this medicine abruptly without consulting with your doctor.
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Missed Dose
Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses.
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Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture. Throw away any medication that is outdated or no longer needed.
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Possible Side Effects
    • Unreported side effects are possible, talk to your healthcare provider if any other symptoms occur.
    • An allergic reaction to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, severe dizziness, or trouble breathing.
    • Some common side effects reported with this medicine include:
      • drowsiness or dizziness
      • dry mouth
      • constipation
      • nausea
      • blurred vision
      • headache
      • weight gain
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    • Elderly patients generally should avoid it because this medicine due to an increase in dizziness resulting in falls.
    • This medicine may cause dizziness or drowsiness.
    • Alcoholic beverages can increase the effects of this medicine and should be avoided.
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Seek medical attention immediately. U.S. residents can call the national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.
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Drug Interactions
    • Talk with your physician or pharmacist if you are taking other medications.
    • Possible drug interactions may occur with this medicine and:
      • Phenobarbital
      • MAO inhibitors (severe)

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For women, it should be avoided during pregnancy and nursing. As with other medications, if you suspect that you may be pregnant, talk to you physician or pharmacist before using this medication.
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More Information

Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other benefits. However, studies have shown that a small number of people (especially children/teenages) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with a doctor about the risks and benefits of antidepressant medication, even if the treatment is not for a mental condition. Tell your doctor immediatley if you notice worsening depression, unusual behavior changes, (including possible suicidal thoughts/attempts), or other mental/mood changes. Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.
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Copyright 2006 PharmClips, Inc. All rights reserved.
This information is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This is general information and should not in any event be construed as specific instructions for individual patients. The publisher does not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein, including any injury and/or damage to any person or property as a matter of product liability, negligence, or otherwise. No warranty, expressed or implied, is made in regard to the contents of this material. The reader is advised to check with their health care provider before making any changes in their drug regimen.

Last reviewed:
  On 8 Aug 2006
  By John M. Grohol, Psy.D.







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Registered: May 2015
Location: LA
Posts: 79
Wed May 20, 2015 Recommended? Yes | Total Spent: None indicated| Rating: 0 

PROS: it works
CONS: none

I frequently order approved medicines by americantrustpills (seriously, this place sucks) free of danger. The fact is that I use to take plenty of it so minimal expense is very important for me.

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New Member

Registered: June 2011
Posts: 1
Mon January 30, 2012 Recommended? Yes | Total Spent: None indicated| Rating: 0 


Hello friend,Great information about this pill. I am so much happy to read this post. Thanks for sharing with us... Good job! Keep posting....

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New Member

Registered: March 2007
Posts: 1
Mon April 2, 2007 Recommended? No | Total Spent: None indicated| Rating: 1 

PROS: none
CONS: suicidal ideations, weight gained

changed to doxepin from prozac to reduce agitation but supposedly to lift up depression... however, depression got worsen and hosility increased...paranoid, tiredness, attempted to overdose to prevent waking up, weight gained up to 2 stones, purple stretch marks over abdomen and arms, cut off the world and people, long term off sick work etc not recommend this to anyone who may have bipolar disorder.

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New Member

Registered: January 2007
Location: san jose, ca
Posts: 3
Tue January 30, 2007 Recommended? Yes | Total Spent: None indicated| Rating: 9 

PROS: sleep is great and medicine does not wear off

I have been talking Doexepin since 2003 for urticaria or hives. They put me on it after taking Prednisone for 10 days. I used to take Atarax for hives but it "wore off" after awhile and did not work at all. Doxepin really "holds" for a full day. I mean symptoms do not ever break through it's amazing.. I am now taking only 10mg at night. I was taking 45mg after being on Prednisone.

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just me wantng to be free

Registered: October 2004
Location: Kentucky, USA
Posts: 14086
Thu September 14, 2006 Recommended? No | Total Spent: None indicated| Rating: 5 

PROS: no initial side effects
CONS: over time, realized that depression was increasing during use

Doxepin is generic for Sinequan. I was using both generic & brand. The use of it had no initial bad side effects that stopped my use of it. However over time, my depression level started to get worse. The depression couldn't get under control, so the med was changed.

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